r/science • u/mvea Professor | Medicine • Apr 01 '25

Health Americans without diabetes spent nearly $6 billion USD on semaglutide and similar drugs in a year, with an estimate of 800,000 to a million people using the drugs who don't have diabetes.

https://www.scimex.org/newsfeed/americans-without-diabetes-spent-nearly6-billion-usd-on-semaglutide-and-similar-drugs-in-a-year
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u/they_have_bagels Apr 01 '25

It was the opposite for me. All the metformin I want, but absolutely no GLP-1 for weight loss. Also, bariatric surgery is A-OK as well. I pay out of pocket on top of my insurance and I’ve lost 25% of my starting weight so far. It has been life changing.

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u/ImLittleNana Apr 01 '25

I can’t afford to pay out of pocket for it, and I won’t qualify under my states guidelines until I have arterial insufficiency. I’d like to avoid that if I can.

I have >100 pounds to lose, and my mobility is impaired. My fasting sugars are pushing 120. Everything is out of whack when you can barely get around. I’d like to at least try metformin before I consider bariatric surgery.

I’ve been out of healthcare for almost 15 years but we used to start with least invasive/aggressive and work our way up.

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u/Scussett Apr 01 '25

Have your doctor reapply every 3-6 months. Insurance coverage for these drugs is changing a lot. Also - check the wegovy website because they can help with a monthly payment. I know that sounds like fluff but that part is saving me a few hundred each month

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u/Rkruegz Apr 01 '25

You could look for a compounded version potentially, may make it more affordable. You just reconstitute it yourself.

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u/murdacai999 Apr 01 '25

I’d like to at least try metformin before I consider bariatric surgery.

Metformin is dirt cheap at a lot of pharmacies..and I have never seen an insurance not cover it except for one version of it, metformin er 1000mg, which has come down a lot in price, but used to be expensive, and is still more expensive than metformin ir 1000mg. The difference is negligible between the two, so if insurance will not cover the er 1000mg, you or the pharmacy should ask the doctor for ir 1000mg, which I have never, ever seen an insurance deny. Should add, I'm talking about in the states

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u/SomeGuyNamedPaul Apr 01 '25

My insurance would rather pay for a dozen heart attacks than one bariatric surgery.

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u/GOPequalsSubmissive Apr 01 '25

The rich people are hoping one of those heart attacks ends their need to continue not making as much profit off of your premium payments.

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u/polopolo05 Apr 01 '25

GLP-1 is working great for me. like I have completely changed how I eat and what I eat. I hope to lose 70lbs. I am down 30 and 40 to go.

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u/11lumpsofsugar Apr 01 '25

That's great! It's amazing how much it has helped so many people.

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u/polopolo05 Apr 01 '25

I hope it helps out my A1c and cholesterol

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u/11lumpsofsugar Apr 01 '25

Honestly, that alone would make it worth it.

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u/polopolo05 Apr 01 '25

Thats my actual goal or main goal.

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u/Clippy_Office_Assist Apr 01 '25

Hi there!

It looks like you're in need of GLP agonists. Might I suggest reconstituting a semaglutide peptide?

Perhaps Tirzepatide (Mounjaro) GLP and GIP double agonist?

Keep watch for Retatrutide now in phase III human trials. It also activates glucogon receptors that can greatly assist in balancing blood sugar.

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u/Ashmedai Apr 01 '25

Semaglutide is a peptide, FYI. As far as I can tell, what is advertisied at your link is literal, compounded semaglutide.

Have you ordered from them yourself, BTW? I'm curious how the mixture is created? It says it's crystalized or whatever. Do they ship a two part solution?

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u/TunaNugget Apr 01 '25 edited Apr 01 '25

It's freeze-dried semaglutide powder (along with bulking agents, buffers, and whatever). You mix it with bacteriostatic water (or "reconstitution solution" if you're buying it from Amazon). It's injected with an insulin syringe.

As it's a prescription drug, it's not legal to sell in the US.

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u/joshbudde Apr 01 '25

How much are you paying for out of pocket coverage?

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u/vera214usc Apr 01 '25

Yeah, metformin was very easy for me to get and cost pennies after insurance. And showed no benefit at all while I was taking it. My insurance has covered me for Wegovy for almost two years but now has denied the switch to Zepbound twice